Green Bay hasn't missed Al Harris much since he suffered a spleen injury in Week 3. Williams, just a second-year player, has filled in admirably with an interception in each of the last three games. Savvy veteran Woodson hasn't let a broken toe he sustained in the season opener bother him and, with a co-league-high four picks, is arguably the best cover corner in the league in the early going this season.
Now comes a stern test for the Packers' defensive backs with the playmaking combo of Harrison and Wayne. The size matchups are in Green Bay's favor to carry out its press coverage at the line, but a misstep in tracking the receivers' routes could be all the difference in letting Harrison and Wayne wreak havoc in the up-tempo attack preferred by quarterback Peyton Manning.
The Colts' dynamic pass-catching duo combined for 16 catches, 249 yards and two touchdowns when the teams last met in 2004 - a 45-31 Indy win in which Harris was the only current Green Bay DB on the field that day.
Packers OTs Chad Clifton and Mark Tauscher vs. Colts DEs Dwight Freeney and Robert Mathis
Lest the Green Bay defense can't slow down Manning and Co., the Packers offense will be forced to try to stay in the game through the air. That means quarterback Aaron Rodgers will need optimum time to set up and throw or buy time by moving outside the pocket.
Keeping formidable speed rushers Freeney and Mathis from running interference falls on aging, but dependable bookends Clifton and Tauscher. The latter have risen to the challenge in recent weeks against the likes of Minnesota's Jared Allen, Atlanta's John Abraham and Seattle's Patrick Kerney. A two-headed monster hell-bent on ball hawking - Freeney (league-leading 33) and Mathis have forced 61 fumbles since 2002 - could be tough to overcome, however.
Colts CB Marlin Jackson vs. Packers WR Greg Jennings
Jackson usually takes on the opposing team's hottest receiver. Jennings is certainly that, currently fifth in the NFL with 34 catches for 653 yards and four touchdowns so far this year. He has a league-leading 19.2 yards per catch.
Packers QB Aaron Rogers vs. Colts DEs Dwight Freeney/Robert Mathis
Rogers has gotten off to a good start as a starter for Green Bay. Freeney and Mathis have both been on a tear over the last five quarters in games with Houston and Baltimore.