The move has not been announced by the team, and Knott was on the team's official list of coaches as of midday Thursday.
Knott, 43, was one of McCarthy's original hires in January 2006. Knott worked mostly with receivers coach Jimmy Robinson, and was responsible for breaking down opponent game film, drawing playbooks and analyzing opponent tendencies.
Knott was a defensive assistant in New Orleans when McCarthy was offensive coordinator and linebackers coach Winston Moss held the same position with the Saints.
Knott joins five defensive assistants — coordinator Bob Sanders, secondary coaches Kurt Schottenheimer and Lionel Washington, defensive tackles coach Robert Nunn and defensive ends coach Carl Hairston — as well as strength and conditioning coach Rock Gullickson as assistants dismissed this week.
Meanwhile, according to the National Football Post, the Packers will interview Denver defensive line coach Bill Johnson for the same post in Green Bay. He also will interview in Seattle and New Orleans. Johnson remains under contract with the Broncos but is being allowed to look for a new employer after coach Mike Shanahan's dismissal. Johnson has worked with 4-3 and 3-4 schemes.