- The Carolina Panthers suffered a number of injuries along the offensive line with Ryan Kalil ruled out before the start of the game and Andrew Norwell leaving after only three plays due to a leg injury. The team had Fernando Velasco step in for Kalil at center and turned to Chris Scott initially at left guard. The team made a switch at halftime though and went with Amini Silatolu who played better in the second half.
- One trend that has developed over the first half of the 2015 season is the Panthers operating out of a two-tight end set. Greg Olsen continues to play every snap, he hasn't missed a single offensive snap this year, which isn't really a big surprise. However, Ed Dickson continues to play about 50% of the team's snaps this year which has been about the norm for this Panthers' offense.
- It was apparent, especially late, for this defensive line that they were starting to run out of gas. The team were missing two key reserves in Dwan Edwards and Mario Addison along the line which saw an increase for the other players. Ryan Delaire saw his playing time increase as he played a season high 41 snaps, which was 16 more than Wes Horton.
- An interesting trend the past two weeks with Shaq Thompson out has been the lack of playing time for linebacker A.J. Klein. After only two snaps against the Philadelphia Eagles, he played 15 snaps against the Colts. This is a drastic difference from the beginning of the season when Klein was filling in for Luke Kuechly and playing almost every snap.