Carolina took advantage of four interceptions, three by rookie cornerback Ricky Manning.
"They aren't going to be denied," said Panthers head coach John Fox, now 3-0 in the postseason.
The first quarter was scoreless as both teams punted twice. The first score of the game was on first-and-10 from the Philadelphia 24-yard line, Jake Delhomme under-threw wide receiver Muhsin Muhammad, who came back against double coverage and caught the touchdown pass in the front of the end zone.
The Eagles answered with a 14-play, 44-yard drive that culminated with a 41-yard field goal by David Akers, but Eagles quarterback McNabb suffered a rib injury when Panthers linebacker Greg Favors tackled him after a seven-yard loss.
On the opening drive of the second half, the Eagles drove to the Panthers 18-yard line, but Ricky Manning picked off McNabb for the second time at the 14-yard line and returning it two yards.
"We were attacking all day," said Manning.
After another Manning interception stopped the Eagles again and the Panthers were scored with 4:18 remaining in the third quarter as running back DeShaun Foster broke five tackles and reaching over the goal line on a one-yard run.
"I'm going to try not to think about the Patriots tonight so I can at least get some sleep," said Delhomme. "I don't want to think about that defense just yet."