Running back Fred Jackson has a simple recipe for making the playoffs.
"We have to win everything at home and go 50 percent on the road and that should get us into the playoffs," Jackson said. "That's how we're approaching it."
The Bills (1-1) are 1-0 on the home portion of this formula after Sunday's determined 33-20 victory over Tampa Bay at Ralph Wilson Stadium, but getting to 2-0 won't be easy.
Buffalo hosts unbeaten New Orleans (2-0) and its high-powered offense next and faces the prospect of playing without four injured starters.
After middle linebacker Paul Posluszny was lost 4-6 weeks with a broken arm against New England, three starters went down against the Buccaneers: cornerback Leodis McKelvin (ankle), right tackle Brad Butler (knee) and tight end Derek Schouman (knee). Reserve tight end Shawn Nelson also went out with a dinged shoulder.
The status of each player won't be known definitively until later in the week.
"We have guys -- I don't like to think of them as backups -- who are starters in waiting," safety Bryan Scott said. "In this game, guys have to be ready to go."
The Bills were more than ready to rebound from a heart-wrenching one-point loss to New England, jumping out to a 17-0 lead over the Buccaneers.
Turnovers prevented Buffalo from finishing drives and putting Tampa Bay away for good, but Terrell Owens' 43-yard touchdown catch -- his first score as a Bill -- did the trick with 9:16 to play.
That atoned for an earlier dropped bomb.
Getting Owens and Evans involved on deep throws is something Buffalo failed to do against the Patriots in Week One. But their mere presence outside is opening up Buffalo's running game.
"If they are going to drop out into coverage, we're going to run the ball with Fred Jackson," Edwards said. "And if they drop down, we are going to throw the ball up top. A balanced attack is pretty hard to stop."
The Bills bent defensively but unlike in New England, didn't break.
"When someone snatches that win from you, it is tremendously hard," Whitner said. "We just wanted to prove to ourselves that we could do it and prove to everyone else that this year, we have a good football team."
They can really prove it by beating New Orleans.
LINEUP WATCH: Jonathan Scott replaced Brad Butler (knee) at right tackle and would likely get the start against New Orleans. Reggie Corner will start if Leodis McKelvin (ankle) can't go at right cornerback. Tight end Derek Schouman's knee injury may not be as serious as first feared but the Bills are down to one healthy tight end, Derek Fine.
-- RT Brad Butler suffered a right knee injury with :52 left in the half and did not return. Tampa Bay defender Stylez White was thrown into Butler's planted leg. His status will be updated later in the week.
-- TE Shawn Nelson left the game in the first half with a shoulder injury and did not return. He had one catch for 13 yards.
-- TE Derek Schouman suffered a right knee injury with 1:03 left in the third quarter. His knee twisted grotesquely as he hit the turf hard after an 8-yard reception and he needed to be carted off. He said afterward there was no structural damage and he was hoping for a quick return.
-- CB Leodis McKelvin suffered an ankle injury in the first half and did not return. He was replaced by Reggie Corner.
-- WR Terrell Owens caught his 140th career touchdown and first as a Bill, a 43-yard strike that iced Sunday's win over Tampa Bay. Owens finished with three catches.
-- WR Lee Evans caught just one pass against Tampa Bay but it was good for 32 yards and a touchdown. It was his 300th catch as a Bill.
-- FS Donte Whitner had eight tackles and returned an interception 75 yards for a touchdown in Sunday's win over Tampa Bay.