Still, familiarity won't be a problem on Sunday in Kansas City.
It was just last season that the Steelers engaged first-year Chiefs QB Matt Cassel in New England, and later, in Super Bowl XLIII, the Steelers were exposed to several of the components and concepts of the offense Kansas City currently runs.
First-year Chiefs head coach Todd Haley thought his experience against the Steelers as the Arizona Cardinals' offensive coordinator last February in Tampa was relevant enough to what might take place at Arrowhead Stadium that he actually watched a tape of that last meeting for the first time this week.
"Kind of an odd experience," Haley said. "It was a painful, painful, painful experience."
The same can be said of Cassel's start for the Patriots against the Steelers last November at Gillette Stadium.
As a fourth-year pro and first-time starter, Cassel succumbed -- as those unfamiliar with the nuances of Dick LeBeau's defense often do -- to the tune of two interceptions, two lost fumbles and a passer rating of 39.4 in a 33-10 loss.
Cassel remembered the gory details with remarkable clarity in a conference call with the Pittsburgh media this week.
Steelers linebacker James Farrior wasn't surprised; the same has repeatedly happened to QBs with more on their resume than Cassel, who opposed the Steelers' defense while lacking a keen understanding of and appreciation for what they were confronting.
"Even when you get a guy (with experience) that's never really faced our defense, we kind of put a number on 'em," Farrior said. "I think we had a good day that day overall."
Expect the Steelers to have another good day tomorrow.
Cassel's more experienced this time around, but a handful of NFL starts and one first-hand exposure to LeBeau's wizardry doesn't exactly make Cassel an expert on what'll be coming at him from all angles.
As for the similarities between the current Kansas City offense and the one Haley coordinated in the desert, the Chiefs may well have a better idea of what theoretically might and might not work against the Steelers than some.
But that was also the case heading into the Denver game, when Josh McDaniels' New England offense was awaiting the Steelers in the Rocky Mountains.
Combine all of that with Ben Roethlisberger's determination to bounce back from a game against Cincinnati in which he admittedly just didn't have it, and the deck appears stacked against Kansas City.