Let's throw out a quick checklist:
One thing is clear. Henderson, who is in his first year as a starter, is likely going to be targeted and he knows he has a long day ahead of him.
The primary job is going to be doing what so few other teams have been able to do – contain Newton. Henderson said he's no stranger to the magic Newton brings to the football field and said he hasn't been shocked by how quickly he has made an impact in the NFL.
"Each week presents a different task for us and he's one of things we have to focus on and try to get him out of the game." Henderson said. "He's playing exceptionally well right now. I'm not really surprised, because I watched him at Auburn. Actually, I made a lot of money betting with Auburn when they won their championship, so I'm familiar with his game and what they do."
He did say, however, that the Vikings won't put a "spy" on Newton – a defender who follows him wherever he goes in hopes of keeping him in the pocket or behind the line of scrimmage. He said the Vikings will continue to do what they do best, not change what they do defensively to tailor their attack to one player.
"Everybody just has to do their job," Henderson said. "If you have responsibility to the quarterback, have contain or whatever the case may be, you just have to do you part, do your job and take care of it. You can't put too much emphasis on one guy."
Although the Vikings struggled late to make defensive stops against the Packers last week, Henderson said the key to beating the Panthers will be slowing down Williams and Stewart. While Newton has impacted the running game and diminished the role of both runners to the offense, the Vikings know the run game remains Carolina's offensive bread and butter. He knows that the Panthers will want to run and stopping their three-headed running attack will be of paramount importance.
"We pride ourselves on being able to stop the run," Henderson said. "They have a strong running game and, if they can establish it, they will stick with it. It's going to be our job to stop them and force them to pass. If we can make them one-dimensional, the advantage will be with us."
As if stopping Newton, Williams and Stewart isn't a big enough challenge, Henderson will also have to contain Olsen and Shockey in the passing game. Henderson said they pose a big challenge to the linebackers because they are so adept at what they do.
"They're both established players and they have been doing this for a long time," Henderson said. "They know how to read defenses and react and both of them will be a big challenge for us. If you focus too much on the running backs and Newton, they have the ability to make plays."
Add to that mix Steve Smith, the NFL's leading receiver, and it's hard to imagine that the Panthers have just two wins. The Vikings will have their hands full with a Panthers offense that appears to be hitting its stride, but Henderson said every team poses its own set of challenges and the Panthers are no exception.
"They have a lot of talented players on offense," Henderson said. "We know we have big job in front of us, especially going there to play them, but we all just have to do our jobs, wrap up tackles when we get the opportunity and make plays. If we do that consistently, we will be fine."
John Holler has been writing about the Vikings for more than a decade for Viking Update. Follow Viking Update on Twitter and discuss this story on our subscriber message board.